ADIPOKINE CONCENTRACTIONS ARE SIMILAR IN FEMORAL ARTERY AND CORONARY VENOUS SINUS BLOOD: EVIDENCE AGAINST IN VIVO ENDOCRINE SECRETION BY HUMAN EPICARDIAL FAT

ADIPOKINE CONCENTRACTIONS ARE SIMILAR IN FEMORAL ARTERY AND CORONARY VENOUS SINUS BLOOD: EVIDENCE AGAINST IN VIVO ENDOCRINE SECRETION BY HUMAN EPICARDIAL FAT
Harold S. Sacks and Eric Johnson (USA)

Abstract
Human epicardial adipose tissue expresses and secretes in vitro hormones and inflammatory cytokines and chemokines collectively termed adipokines. We hypothesized that human epicardial fat did not secrete adipokines into coronary blood under basal conditions in vivo. Adiponectin, leptin, resistin, tumor necrosis factor-α, monocyte chemoattractant protein-1, active plasminogen-activator inhibitor-1, interleukin-1β,-6,-8 and vascular endothelial growth factor were measured simultaneously in femoral arterial (a surrogate for coronary arterial) blood and coronary sinus venous blood from eleven patients, mostly young non-obese women, without known heart disease undergoing cardiac catheterisation for radioablation of supraventricular tachycardia. Mean adipokine concentrations were not significantly different in both vessels. In contrast, free fatty acid levels were significantly higher in femoral arterial than coronary sinus blood in keeping with net uptake of free fatty acids by the myocardium. Femoral artery levels of monocyte chemoattractant protein-1, active plasminogen activator inhibitor-1, leptin and resistin showed positive correlations with BMI in descending order of significance but adiponectin showed no relationship. Values for the other adipokines were below the assay detection limit in several patients negating the use of regression analysis. As opposed to their secretion in vitro, the adipokines described above are not secreted into coronary blood by human epicardial adipose tissue under near-normal basal conditions in vivo and are more likely released into the interstitium of the myocardium and coronary vessels to function as local paracrine regulators.

Adipobiology 2009; 1: 51-56

Key words: adipose tissue, adipokines, inflammation, paracrine, gradients


Received 15 December 2008, accepted 21 January 2009.
Correspondence and reprint request: Dr Harold S. Sacks, 6027 Walnut Grove Road, Suite 307, Memphis, TN 38120, USA.
Tel.: 901 681 0346, Fax: 901 682 7737,
Email: hsacks@hotmail.com

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