PHOSPHATIDYLSERINE, ANOTHER PLAYER IN MACROPHAGE RECRUITMENT IN WHITE ADIPOSE TISSUE?
Johan Renes (The Netherlands)
Macrophage in’ltration in white adipose tissue (WAT) underlies the development of the obesity-associated chronic in=ammatory state. In this article current knowledge is reviewed with respect to adipocyte-driven mechanisms responsible for macrophage recruitment and activation in WAT. Adipocyte hypertrophy, adipocyte hypoxia, altered adipokine pro’les under stress conditions and adipocyte death is discussed. In ad- dition, new data is provided that shows phosphatidylserine exposure in human adi- pocytes under hypoxic conditions. This may represent an additional mechanism that plays a role in macrophage recruitment in WAT.
Adipobiology 2010; 2:23-32
Keywords: adipocytes, hypoxia, adipokines, adipocyte death, phospholipid scrambling
Received 10 December 2010, accepted 19 December 2010.
Correspondence: Dr Johan Renes, Department of Human Biology, Maastricht University, P.O. Box 616, 6200 MD, Maastricht,
The Netherlands. Tel.: +31 (0)43 388 1633, Fax: +31 (0)43 367 0976,