AdIPOSE-DERIVEd STEM CELLS AS A REMEDY
Anton B. Tonchev, Luigi Aloe, Jerzy Bełtowski, Gorana Rančić, Vladmila Bojanić, Pepa Atanassova, Peter I. Ghenev, and George N. Chaldakov (Bulgaria, Italy, Poland, Serbia)
Adipobiology of stem cells is reaching enthusiastic proportions in today’s regenerative medicine. Current interest in the adipose-derived stem cells (ADSC) stems from their multilineage differentiation potential, and ease of derivation in larger quantities using less invasive methods, compared with other stem cell types. The possible benefits of ADSC-based therapy may be mediated by both cell proliferation/differentiation and paracrine secretion. Adipose tissue’s secretome includes adipokines (growth factors, cytokines, chemokines, neuropeptides, hypothalamic hormones/releasing factors), steroid hormones, free fatty acids, prostaglandins, and endocannabinoinds. The present review, focusing on adipose tissue secretory activity, also highlights the possible implication of ADSC in the therapy of various disorders, particularly neurodegenerative diseases, myocardial infarction and stroke as well as gut, liver and skin diseases.
Adipobiology 2010; 2:51-56
Key words: adipose tissue, disease, growth factors, secretion, therapy
Received 12 December 2010, accepted 21 December 2010.
Correspondence to Dr George N. Chaldakov, Laboratory of Cell Biology, Medical University, BG-9002 Varna, Bulgaria.
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