BONE-DERIVED SECRETORY PROTEINS AND GLUCOSE AND ENERGY HOMEOSTASIS
Gumpeny R. Sridhar and Gumpeny Lakshmi (India)
Clinical and experimental studies demonstrate an interaction among bones, adipose tissue and diabetes mellitus: obese women have lower risk of fractures, whereas diabetes and hypertension were associated with osteopenia and osteoporosis. Today, bone is considered not solely as a supporting and protective structure, but also an active endocrine organ producing secretory proteins collectively termed osteokines. In this presentation, the role of two of these factors, leptin and osteocalcin, as well as the transcription factors FOX01 and ATF4, in the control of glucose and energy homeostasis is briefly highlighted.
Adipobiology 2010; 2:67-71
Key words: adipokines, osetokines, metabolism, skeleton
Received 15 December 2010, accepted 27 December 2010.
Correspondence: Dr Sridhar R. Gumpeny, Endocrine and Diabetes Centre, 15-12-15 Krishnanagar, Visakhapatnam 530002, India.