Neuroimmune hypothesis of atherosclerosis
George TV. Chaldakov, Marco Fiore, Ivan S. Stankulov, Viviana Triaca, Peter I. Ghenev, and Luigi Aloe ( Bulgaria and Italy )
Although “many roads lead to atheroma”, the prevailing hypothesis at present is the Russell Ross’ response-to-injury hypothesis, which sates that atherosclerosis is an inflammatory disease that involves several aspects of wound healing. It is noteworthy that, emphasized by the current studies of neurotrophic factors and nerve-immune cell interactions, neuroimmune mechanisms are increasingly implicated in the pathogenesis of a number of inflammatory diseases. Here we highlight the possibility that neuroimmune mechanisms, including the participation of neurotrophic factors and immune cells, may also be involved in the process of atherogenesis.
Biomed Rev 1999; 10: 37-44.
Received 25 July 1999 and accepted 19 October 1999.
Correspondence and reprint request to Dr George N. Chaldakov, Division of Electron Microscopy, Medical University, BG-9002 Varna, Bulgaria. Tel.: 35952 454 394; 21261, Fax: 359 52 222 584