Neurolipidology: interactions of nerves, neurotrophic factors, and lipids
George N. Chaldakov and Luigi Aloe ( Bulgaria and Italy )
Here we highlight current data of the involvement of cholesterol, lipoproteins and lipoprotein receptors in the neuronal development and of neurotrophic factors in the lipid and glucose metabolism. We term these interactions neuro- lipidology. And argue that in addition to its implication in neurodegenerative diseases such as Alzheimer’s disease (1), neurolipidology may have wide-ranging potential within a variety of nonneuronal fields, including cardiovascular disease, particularly, atherosclerosis and related disorders.
BiomedRev 1999; 10:101-113.
Received 16 August 1999 and accepted 20 November 1999.
Correspondence and reprint request to Dr George N. Chaldakov, Division of Electron Microscopy, Medical University , B G-9002 Varna, Bulgaria. Tel.: 359 52 454 394, Fax: 359 52 222 584