PAAT: a path to atherosclerosis
Ivan S. Stankulov, LuigiAloe, Peter I. Ghenev, Luigi Manni, Pavel Pavlov, Marco Fiore, and GeorgeN.Chaldakov (Bulgaria, Italy)
The artery wall consists ofintima, media, and adventitia, the latter gradually transiting into the periadventitial adipose tissue (PAAT). Although many paths lead to atherosclerosis, the prevailing paradigm at present is Russell Ross’s response-to-injury hypothesis, which states that atherosclerosis is a chronic inflammatory disease. This hypothesis considers the intimal smooth muscle cell proliferation as a key event in the generation, development and complication of atherosclerosis. Thus the potentially important role played by adventitial fibroblasts/myofibroblasts in atherosclerosis and postangioplasty restenosis, suggesting therapeutic perspectives targeted to these particular cells, has been neglected. Here we go further away from the intima, and focus on the potential involvement of PAAT in the process of atherogenesis and angioplasty-induced restenosis.
Biomed Rev 2002; 13: 63-65.
Received 7 November 2002 and accepted 3 December 2002.
Correspondence and reprint requests to Dr George N. Chaldakov, Division of Cell Biology, Department of Forensic Medicine. Medical University, BG-9002 Varna, Bulgaria. Tel: 359 52 454 394; 359 52 606 786; Fax: 359 52 222 584;