CROSSTALK BETWEEN BRAIN-DERIVED NEUROTROPHIC FACTOR AND N-METHYL-D-ASPARTATE RECEPTOR SIGNALING IN NEURONS

CROSSTALK BETWEEN BRAIN-DERIVED NEUROTROPHIC FACTOR
AND N-METHYL-D-ASPARTATE RECEPTOR SIGNALING IN NEURONS
Danko D. Georgiev, Hideo Taniura, Yuki Kambe, and Yukio Yoneda
Laboratory of Molecular Pharmacology, Division of Pharmaceutical Sciences, Kanazawa University Graduate School of Natural Science and Technology, Kanazawa, Ishikawa 920-1192, Japan


Glutamate is the major excitatory neurotransmitter in brain exerting prosurvival effect on neurons via N-methyl-D-aspartate receptor (NMDAR) signaling under physiological conditions. However in pathological circumstances such as ischemia, NMDARs might have proapoptotic excitotoxic activity. In contrast brain-derived neurotrophic factor (BDNF) signaling via tropomyosinrelated receptor kinase B (TrkB) has been largely considered to promote neuronal differentiation, plasticity and survival during normal development, and protect neurons in pathophysiological conditions antagonizing the NMDAR-mediated excitotoxic cell death. In this review we summarize recent evidence for the existent crosstalk and positive feedback loops between the BDNF and NMDAR signaling and point out some of the important specific features of each signaling pathway.
Biomed Rev 2008; 19: 17-27.

Key words: NMDA receptor, BDNF, neurotrophins


Received 2 October 2008, accepted 7 November 2008.
Correspondence and reprint request to Dr Danko Georgiev, Department of Psychiatry and Neurobiology, Graduate School of Medical Science, Kanazawa University, 13-1 Takaramachi, Kanazawa, Ishikawa 920-8641, Japan.
E-mail: danko@med.kanazawa-u.ac.jp

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