The C-type natriuretic peptide system in the testis: a phisiological role of neuroactive factors in Leydig cells

The C-type natriuretic peptide system in the testis: a phisiological role of neuroactive factors in Leydig cells
Ralf Middendorff, Dieter muller, and Adolf F. Holstein ( Germany )

Androgen production is the primary function of testicular Leydig cells (1). Recently, Leydig cells of the human testis have been shown to possess, along with well developed smooth endoplasmic reticulum, cytoplasmic vesicles and storage granules similar to those found in neuroendocrine and nerve cells (2). Moreover, a series of nerve cell-specific substances has been detected in Leydig cells (reviewed in 3, 4). However, little is known about the physiological role of these molecules in testicular function.
Biomed Rev 1997; 8: 111-117
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Received for publication 7 November 1997 and accepted 29 November 1997.

Correspondence and reprint requests to Dr Ralf Middendorff. Institute of Anatomy, University of Hamburg, MartinistraBe 52, D-20246 Hamburg, Germany. Tel: 49 (40)4717 3576, Fax: 49 (40)4717 4966
E-mail: davidoff@uke.uni-hamburg.de

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