Biological functions of lysosomal membrane-associated glycoproteins

Biological functions of lysosomal membrane-associated glycoproteins
Victoria Sarafian, Michel Jadot, Simone Wattiaux-De Coninck, and Robert Wattiaux ( Bulgaria, Belgium )

Lysosomes are the final repository of degradation products from the extracellular and intracellular spaces. The lysosomal membrane forms a unique vacuole participating in both endocytosis and autophagocytosis (1). It is extremely resistant to degradation by lysosomal hydrolases, maintains an acidic intralysosomal environment, transports amino acids and oligosaccharides produced by lysosomal hydrolases, in teracts and fuses with other membrane organelles, such as endosomes and phagosomes, and with the plasma membrane: (2, 3).
Biomed Rev 1997; 8: 119-125
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Received for publication 12 October 1997 and accepted 2 November 1997.

Correspondence and reprint requests to Dr Victoria Sarafian, De partment of Biology, Medical Institute, 15 A V. Aprilov Blvd, BG-4000 Plovdiv,Bulgaria.Tel: 359(32)444 358;265986,Fax: 359(32)443984; 442194
E-mail: sarafian@mbox.digsys.bg

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