Sex differences of parvalbumin-immunoreactive neurons in the rat brain

Sex differences of parvalbumin-immunoreactive neurons in the rat brain
Nadya Stefanova, Anastassia Bozhilova-Pastirova, and Wladimir Ovtscharoff (Bulgaria)

During the last two decades numerous studies have proven the existence of sexual dimorphism in the brain of lower verte brates, birds, and mammals. Differences between males and females have been found in various components of central nervous system (CNS), including volumes of certain nuclei, numbers of neurons and synaptic contacts, size of somata and outgrowths, as well as differences in neurolransmitter systems. The mechanisms by which these dimorphic features appear remain an open question for further elucidation. It is not clear yet how the morphological variations observed between sexes during development could be related to functional consequences in the adult organism.
Biomed Rev 1997; 7: 91-96
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Rec eived for publication 17 July 1997 and accepted 3 November 1997.

Correspondence and reprint requests to Dr Anastassia Bozhilova-Pastirova, Department of Anatomy and Histology, Medical University, 2 Zdrave Street, BG-1431 Sofia, Bulgaria. Tel: 359 (2) 518 623,Fax: 359 (2) 518 783,
E-mail: bolzilov@mediae.acad.bg

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