Are there functional progenitor cells in the adult brain parenchyma?
Anton B. Tonchev (Bulgaria)
The subventricular zone (SVZ) of the anterior horn of the lateral ventricle and the subgranular zone (SGZ) of the hippocampal dentate gyrus are the only regions of the adult brain that are widely recognized to contain neural progenitor cells – precursors capable of producing both neurons and glia. However, recent evidence suggests that such cells may exist also outside SVZ and SGZ, in the parenchyma of neocortex and striatum. This opens new possibilities for progenitor cell manipulation in situ with consequent development of novel progenitor-based strategies for the treatment of human neurological disease.
Biomed Rev 2003; 14: 121-125
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Received 10 October 2003 and accepted 10 December 2003.
Correspondence and reprint requests to Dr Anton B. Tonchev, Division of Cell Biology, Department of Forensic Medicine, Medical University, BG-9002 Varna, Bulgaria.
E-mail: atontchev@yahoo.com
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