Endogenous urea as endocoid: an extrarenal focus
Nikolai D. Temnyalov (Bulgaria)
The present position article summarizes briefly own and literature data concerning the characterization of endogenous urea at extrarenal level in animal and human organism. Both under in vivo and in vitro conditions, we apply urea at physiological and pathological concentrations. We found that urea is an endogenous nonspecific beta-adrenergic receptor antagonist-nonselective, noncompetitive, reversible and nontoxic. Hence we suggest the endogenous urea to be included in the list of endocoids (autacoids).
Biomed Rev 2004; 15: 77-80.
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Received 10 May 2004 and accepted 12 November 2004.
Correspondence and reprint request to Dr Nikolai D. Temnyalov, Division of Preclinical and Clinical Pharmacology, Medical University, BG-9002 Varna, Bulgaria. Tel.: 359 52 623 896, Fax: 359 52 650 019.
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