Mast cells, vasoactive intestinal peptide (VIP), and the hemorrhagic shock: a possible relation ship?
The key mechanisms associated with irreversible hemorrhagic shock have no so far been elucidated. The involvement of mast cells in this phenomenon, however, has already been studied. On the other hand, fl-endorphine and various opiates, or any stressful stimuli mediated by endogenous opiates, cause mast cell degranulation and histamine
release, as the study of the related literature shows. Hemorrhagic shock is one such stressful stimulus that leads to an increase in the plasma levels of endogenous opioids, especially fl-endorphine. During hemorrhagic shock, therefore, mast cells can be activated by an elevation of the f3 endorphine level; and the degranulatedproducts of mast cells, histamine in particular, may contribute to the progress of hemorrhagic shock to the irreversible state.
Biomed Rev 1993; 2: 37-46