PATHOGENESIS OF AMYOTROPHIC LATERAL SCLEROSIS

PATHOGENESIS OF AMYOTROPHIC LATERAL SCLEROSIS

Magdalena Kuźma-Kozakiewicz
Department of Neurology, Medical University of Warsaw, Warsaw, Poland

Amyotrophic lateral sclerosis is a devastating neurodegenerative disease affecting both upper and lower motor neuron. Despiteextensive research the primary cause of the disease has not been indentified and the causative treatment is lacking. The present article describes mechanisms involved in the disease development and progression, including oxidative stress, excitotoxicity, mitochondrial dysfunction, protein aggregation, RNA processing, alterations of cytoskeleton functions and axonal transport, glial cell involvement and programmed cell death.
Biomed Rev 2011; 22: 7-14.

Key words: apoptosis, axonal transport, glial cells, glutamate excitoxicity, mitochondrial dysfunction, oxidative stress, superoxide dismutase


Received 20 December 2011, revised 28 December 2011, accepted 29 December 2011.
Correspondence: Magdalena Kuźma-Kozakiewicz, MD, PhD, Department of Neurology, Medical University of Warsaw,
Banacha 1a, PL- 02-097 Warsaw, Poland.
Tel.: +48 22 5992 857; Fax: +48 22 5991 857;
E-mail: magdalena.kuzma@wum.edu.pl

PDF (369 Kb)