Mast cells and mast cell growth factor: possible role in auricular thrombosis
Hans C. Bankl, Thaddaus Radaszkiewicz, and Peter Valent
Although mast cells have been implicated in many vascular and inflammatory reactions, the mechanisms underlying such mast cell-dependent processes have not been fully clarified. Recently we have established an association bet ween mast cells and local thrombus formation. The most useful model for studying molecular mechanisms of mast cellthrombosis interactions appeared to be auricular thrombosis. In the present review we summarize our findings in patients with auricular thrombosis with regard to functionally important molecules that can either be expressed and released by cardiac mast cells or interact with mast cells via distinct cell surface molecules. The potential prothrombolytic function of mast cells in atrial thrombosis is discussed.
Biomed Rev 1995; 4: 29-34.