A novel virus removal filter and its application
Sei-Ichi Manabe andNaoki Yamamoto ( Japan )
The novel virus removal membrane B MMand the commercially available filter PLANOVAR based on this system provide results both reproducible and predictable for virus removal based on a sieving mechanism. The BMMshows good removability of most viruses, including human immunodeficiency virus, hepatitis B and C and other microorganisms. In addition, immune complexes can be removed efficiently with a good protein permeability. Although BMMhas already been shown to be effective in the field of drug manufacture, the combination of virus removal using BMM with virus inactivation offers opportunities for the wider clinical application of BMM, including blood transfusion.
Biomed Rev 1996; 6: 95-109.